If words are weapons, Susie Essman is a freaking ninja. She created an instantly classic character as Susie Greene on HBO’s Curb Your Enthusiasm, launching profanity-laced epithets at husband Jeff (played by Jeff Garlin) at the drop of a hat with absolute bile and conviction. Her character became so famous that people now stop her in the street just to have her utter the phrase, “You fat f*ck!” Most comedians could hang their hat on such an achievement, but that’s just a small part of Essman’s repertoire. She’s also a writer, television producer and accomplished stand-up comedian, and she’ll bring her talents to the Venetian this weekend as part of the property’s Lipshtick series, highlighting the top female comics in the business. Just take our advice and don’t talk during her performance—unless you like being called … well, you know.

Susie Essman September 6, 7:30 p.m., $52-$96. Venetian, 702-414-9000.