Cinco de Mayo at Hussong’s Are you the life of parties you’ve never attended? Is your reputation expanding faster than the universe? Go up against Deadliest Catch’s Travis Arket as he competes in the cantina’s Most Interesting Man in the World contest. Enter for your shot at some sweet prizes, or attend for the $3 Dos Equis drafts and $5-$9 margaritas. May 5, contest at 7 p.m., free entry.

Cinco de Chuy at Tao Celebrate the usually debauched fifth day of May with Chelsea Handler’s sidekick and favorite “little nugget,” Chuy Bravo. The Chelsea Lately star isn’t your only reason to party it up at the Venetian, as all ladies dressed as sexy señoritas will compete for a grand prize of $2K! May 5, doors 10 p.m., $20 men, $10 women, local ladies free.

Ditch Fridays Kick-Off at the Palms The dog ate your laptop. Your Post-It and paper clip allergies are really acting up. A strange case of cubicle-itis has plagued the final day of your work week. Whatever works, just ditch the office for some fun in the sun with Hugh Hefner and a pack of Playboy Playmates! May 6, doors noon, $25 and up, local ladies free.

Mike Posner & Chris Brown at Pure If anything, it certainly is a high-charting weekend at Pure. Mike Posner (No. 31 on the latest Billboard Hot 100) performs at the Caesars nightspot this Friday (after a daytime appearance at Wet Republic), followed by Chris Brown (No. 8) hosting his Saturday night birthday bash. That lineup is definitely something to say “Yeah 3X” to! May 6-7, doors 10 p.m., $30 men, $20 women.

DJ Apl.De.Ap at Liquid Fergie constantly celebrates in Sin City, and Will.i.am is no stranger to Vegas nightlife. What about the other two Black Eyed Peas? Meet another creatively punctuated Pea at Aria’s dayclub this Saturday, as he spins a special celebrity DJ set. May 7, doors 11 a.m., $40 men, $10 women.

Ke$ha at Chateau Did you wake up feelin’ like P. Diddy, too? Then remember to brush your teeth with a bottle of Jack and fight till you see the sunlight at Chateau. Pop superstar Ke$ha performs for her official Get Sleazy tour afterparty. May 7, doors 10 p.m., $30 men, $20 women, local ladies free.

Kentucky Derby at PBR Rock Bar The Run for the Roses is here again, and that means one thing for the ladies: big hats. Embrace your inner Southern belle at the Miracle Mile bar. All women wearing colossal caps receive open bar from 1:30 to 2:30 p.m. Patrons also can enjoy PBR’s signature cocktails, the Hat Bender and the Southern Hospitality, for $5 apiece. May 7, 1:30 p.m., free entry.

Supercross at Body English Yes, you read that right! The now-closed Hard Rock Hotel venue is opening its doors for one night only. Carey Hart partners with Dodge Motorsports and supercross athletes from Monster and his Hart & Huntington team to host a night of action sports mania, with DJ Bobby B of the Kottonmouth Kings spinning the special nightlife experience. May 7, 11 p.m., no cover.